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> Medicinal
Chemistry > Environmental, Pharmaceutical and Bioanalytical
Center |
Environmental,
Pharmaceutical and Bioanalytical Center |
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The
research group of the analytical center is a team
of professionals at the forefront of their disciplines,
with over 20 years of experience in the area of
pharmaceutical, biological and environmental systems.
R&D at the center is conducted using state-of-the-art
technologies and assisted by active collaboration
with various research groups at IIBR in the fields
of organic and medicinal chemistry, pharmacology,
biology and environmental sciences.
The center is active in several areas of R&D offering
comprehensive analytical solutions. Methods are
developed for the complete analytical process, including
sampling, separation, measurement and computerized
data processing. |
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Environmental
and toxic pollutants |
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The
center develops improved methods for sensitive detection
and identification of trace amounts of pollutants
and markers ranging from volatile organics through
non-volatile and thermolabile compounds in environmental
matrices such as air, water, soil and in physiological
media. The center developed unique capabilities
for detection and identification of materials relevant
to the Chemical Weapons Convention (CWC). |
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Pharmaceutical
research |
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The
center's R&D activity also encompasses development
of methodology for detection, identification and
quantitation of therapeutic drugs and of their decomposition
products as well as their metabolites in physiological
media. |
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Biological
Mass Spectrometry |
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Methodologies
for characterization of whole bacterial cells, proteins,
peptides and exogenous materials in physiological
media are developed in this center. |
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Thermal
desorption-GC/MS for vapor phase analysis |
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| LC/MS/MS
analysis of environmental samples |
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Technologies |
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Gas chromatography (GC)
with a wide range of specific detectors (NPD,
FPD, ECD, FID, PFPD, AED)
Gas chromatography mass
spectrometry (GC/MS) using EI, CI or NICI ionization
techniques coupled on line with specific detectors
such as FPD, PFPD and NPD
Thermal desorption unit
coupled on line with GC/MS (EI) equipped also
with an FPD
Tandem mass spectrometry
(GC/MS/MS) for high specificity and structure
elucidation
High resolution GC/MS
for accurate mass measurement
High performance liquid
chromatography (HPLC) with UV Diode array detector |
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High performance liquid
chromatography mass spectrometry (LC/MS/MS) utilizing
electrospray (ESI) or atmospheric pressure chemical
ionization (APCI) techniques, coupled on line
with a diode array UV detector
Matrix assisted laser
desorption time of flight mass spectrometry (MALDI-TOF-MS)
Multi purpose sampler
(MPS) coupled with GC and GC/MS for headspace
and gas injections
Solid phase micro extraction
(SPME)
Super critical fluid
extraction (SFE) |
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