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> Medicinal
Chemistry > Design and Synthesis of Biologically Active
Molecules |
Design
and Synthesis of
Biologically Active Molecules |
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This center has vast and long-standing
experience in the syntheses and structural analyses of
a wide range of chemicals. Complex chemical syntheses
are now achieved by recently introduced innovative technologies,
such as combinatorial chemistry, and are monitored by
solid state NMR techniques.
These techniques and analytical tools are routinely employed
for elucidation of reaction mechanism, development of
novel reaction pathways, as well as for structure-activity
relationship studies which are complemented by toxicological
and pharmacological evaluation in other departments of
IIBR. |
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Robotic liquid handler for automated analyses |
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The
main R&D activities include: |
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Evaluation
of existing and novel decontamination solutions: |
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Detecting minute quantities
of organic compounds utilizing a variety of analytical
methods, including NMR, solid state NMR, GC-MS and enzyme
inhibition
Employing various dispersion
methods for increasing efficacy of decontamination solutions,
such as liquid, aerosol, fog and foam states |
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Design
and synthesis of combinatorial libraries for screening
of biologically active compounds and environmental impurities: |
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Libraries of compounds are
produced using solution or solid-phase chemistry by
the parallel synthetic approach
Isolation, purification and
characterization strategies, have been developed specifically
for these types of syntheses |
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Implementation
of modern solution and solid state NMR techniques for
structure elucidation and environmental fate of various
compounds.
These include: |
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Measurements of X nuclei such
as 31P, 19F, 13C, 15N
High Resolution Magic Angle
Spinning (HR-MAS)
2D techniques such as COSY,
TOCSY, C-H and P-H correlation |
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State-of-the-art NMR instrumentation |
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