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> Medicinal
Chemistry > Pharmacological, Toxicological, Physiological
and Behavioral Assessment |
Pharmacological,
Toxicological, Physiological
and Behavioral Assessment |
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IIBR’s
advanced pharmacological and neuroscience projects are
supported by a wide spectrum of techniques and laboratories,
dedicated to pharmacology, toxicology, physiology, clinical
biochemistry, histology, animal and human performance
and behavior. |
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Research
activities are focused on: |
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Treatment and therapy of the
effects caused by toxic compounds used in agriculture
and industry
Prevention, treatment and therapy
of the effects caused by chemical and thermal burns
Ocular studies of chemical
and physical injuries to the cornea and retina, and
their prevention and treatment
Physiological studies of seizure
activity and prevention of the resulting irreversible
brain damage
Stress mechanisms and preventive
therapeutic means against aging and stress-induced neuronal
damage
Investigation of inflammatory
modulators using ex-vivo and tissue-culture methods
Pharmacokinetic studies and
investigation of drug delivery systems
Drug-receptor interactions
and physiological responses mediated by distinct neurotransmitter
receptor sub-types |
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| Physiological
studies of seizure activity and prevention of its irreversible
brain damages |
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| In-vivo
assessment of seizure activity and its attenuation, in
freely moving animals |
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Untreated |
Treated |
| Prevention
of brain damage - histological assessment |
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| Electrophysiology
and pharmacology of the heart |
Immunohistochemical staining of apoptotic skin damage |
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Assessment
of Human Performance and Behavior |
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IIBR
has developed a computerized test battery - CTB-HPB
– that monitors performance and behavioral
changes due to the use of therapeutic drugs, physical
environmental stressors and neurological damage.
The system is based on tests probing psychological
processes such as perception, attention, memory,
reasoning, time estimation, psychomotor functioning,
planning, situation assessment, decision making,
problem solving and communication, with emphasis
on vision research.
The CTB-HPB has been used successfully in several
clinical studies. |
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| Assessment
of ocular injuries |
In-vivo corneal examination using specular microscopy |
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Evaluation of retinal function and injuries |
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Corneal innervation in whole-mount preparation stained
for cholinesterase activity. |
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