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Cell Culture Technologies
  The IIBR biotechnology and genetic engineering teams offer extensive professional skills in production of native and recombinant proteins in highly efficient expression systems:  
 
  • Generation of human or mammalian cell clones, exhibiting consistent high production / secretion of the protein of interest over a long period of time as well as favored post-translation processing.
  • Evaluation of recombinant producer cells, serving as candidates for high-level protein production in appropriate bacterial systems or established eukaryotic cells.
  • Development of efficient cultivation systems of mammalian anchorage-dependent cells in surface propagators, fixed-bed reactors and stirred microcarrier cultures.
  • Development of batch, fed batch and perfusion cultures of suspended cells in large-scale bioreactors according to cGMP regulations.
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    Propagation of recombinant cells
    in a multitray system
    Process optimization in R&D pilot plant fermentors
     
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