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IIBR
is investigating viral and bacterial pathogenesis mechanisms
in an attempt to design new strategies for vaccine and
drug development, for the evaluation of novel modes of
therapy as well as for diagnostic purposes.
The R&D approach comprises of classical microbiology methodologies,
a vast array of molecular biology procedures, tissue culture
and cytotoxic assays, immunological methods and in-vivo
studies including: |
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Development
of pathogen-specific in-vitro models of infection
Development of animal models for
infection: different species, varying genetic backgrounds
and well-characterized immune-deficient animal model
systems
Development of attenuated pathogen
strains, using powerful genetic methods for random mutagenesis
and in-vivo selection (STM), or targeted mutagenesis
in genes selected by bioinformatic methodologies, screening
for new genes involved in pathogenesis |
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Deciphering
host-pathogen interactions with emphasis on the interplay
between pathogen-macrophage and pathogen-nervous system
(including blood-brain-barrier penetration). Analyses
include dissection, at the molecular level, of extra
and intra-cellular signaling pathways
Production of polyclonal hyperimmune
antisera and monoclonal antibodies for neutralization
of various components responsible for virulence
Evaluation of T-cell related immunity
to infectious diseases using state of the art methodologies,
including flow cytometry approaches
Generation of infectious RNA libraries
to produce different viral recombinant products for
assessment of their infectivity and immunoneutralization
potencies in cells |
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