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IIBR's
center for the diagnosis of infectious diseases serves
as a national reference microbiological laboratory for
the diagnosis of pathogenic microorganisms (e.g. rickettsial
and ehrlichial diseases), acts as a WHO-approved national
reference center for leptospirae and offers diagnostic
consultation to hospitals and clinics in Israel. The center's
activities also include the development of diagnostic
procedures for bioterrorism threat agents.
The R&D groups are engaged in the development of rapid,
sensitive and specific diagnostic methods (and reagents)
for pathogen detection and identification, in both clinical
and environmental samples. These include: |
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Transmission
electron microscopy of immunogold labeled B.anthracis
spores |
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Organism cultivation and subsequent
characterization (classical microbiology)
Genetic pathogen identification
(e.g. real-time PCR)
Detection of host immune response
by serological tests
Visual detection of pathogens in
the host by immunofluorescence
Immunoenzymatic methods
Lateral immunochromatography
Immunoelectron microscopy analysis
Polypeptide profile analysis (Western-blots,
MALDI-TOF/MS)
In-vitro/in-vivo infectivity
evaluation |
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The
center also produces antigens, antibodies
and conjugates as reagents for the diagnosis of pathogenic
organisms (e.g. rickettsial and ehrlichial and West Nile
diseases). |
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