IIBR has a vast and long-standing experience in the syntheses and structural analyses of a wide range of chemicals. Complex chemical syntheses are achieved by innovative technologies such as combinatorial chemistry and dry box manipulations, and are monitored by liquid and solid state NMR technologies.
These techniques and analytical tools combined, with ab-initio quantum-mechanical calculations, are routinely employed for elucidation of reaction mechanisms, development of novel reaction pathways, as well as for structure-activity relationship studies; these are complemented by toxicological and pharmacological evaluation in other departments of IIBR.
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The department's main R&D activities include:
Design and syntheses of biologically active compounds:
- Tailor made synthesis of organo-phosphorus compounds.
- Libraries of compounds are produced using solution or solid-phase chemistry by a parallel combinatotial synthesis approach.
- Isolation, purification and characterization strategies have been developed specifically for these types of syntheses.
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Development and evaluation of commercial and novel proprietary decontamination reagents and formulations:
- Using controlled environment laboratory systems the decontamination efficacies and the compatibility of the reagents with structural matrices are systematically tested.
- Various dispersion methods to increase the efficacy of decontamination media, such as liquid aerosol, fog and foam states are tested.
Modern analytical techniques employed for structure elucidation and investigation of the environmental fate of various compounds, include:
- NMR measurements of nuclei such as 31P, 19F, 13C, 15N
- Solid state NMR using High Resolution Magic Angle Spinning (HR-MAS)
- 2D NMR techniques such as Cosy, Tocsy, C-H and P-H correlation
- GC, GC/MS, HPLC and LC/MS
Syntheses of fluorescent nano-particles
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